With the prick of a needle, the battle against Covid-19 took what could be a decisive turn Monday as the first federally approved coronavirus vaccine was injected into the arm of an American.
Sandra Lindsay, an intensive care unit nurse who has been on the front lines of the battle against a virus that's killed more than 300,000 people in the United States alone, joined in the applause moments after the first dose was injected into her left arm.
"I feel hopeful today, relieved," Lindsay, who works at the Long Island Jewish Medical Center in the New York City borough of Queens, said after the historic moment was livestreamed by New York Gov. Andrew Cuomo. "I feel the healing is coming. I hope this marks the beginning of the end of the very painful time in our history."
Cuomo, whose state was among the hardest hit in the earliest days of the pandemic, hailed the vaccine as "the weapon that will end the war."
"How fitting that she was the first to get the shot," New York City Mayor Bill de Blasio said of Lindsay.
Within minutes, President Donald Trump posted on Twitter: "“First Vaccine Administered. Congratulations USA! Congratulations WORLD!”
Developed by the German company BioNTech and its U.S. partner, Pfizer, the Covid-19 vaccine was given emergency use authorization by the Food and Drug Administration on Friday night.
The first trucks bearing the doses departed Pfizer's plant in Portage, Michigan, on Sunday and the company expects to deliver 2.9 million doses to 636 predetermined locations by the end of this week.
By Sunday evening, an American Airlines Boeing 777-200 packed with vaccines had taken off from the Chicago O'Hare International Airport bound for Miami. Florida has reported more than 1.1 million cases of the coronavirus, according to the latest NBC News data.
"The cavalry is on the way," Dr. Dave Chokshi, the New York City health commissioner, said Monday.
It was the start of what is shaping up to be a colossal logistical challenge, with cargo trucks and planes fanning out across the country. All the while, these vaccines must be kept at minus 94 Fahrenheit and transported to their destinations in special boxes packed with dry ice.
"We now believe that the first individuals will be vaccinated here in the commonwealth tomorrow morning," Kentucky Gov. Andy Beshear said in a statement Sunday. "We are less than 24 hours away from the beginning of the end of this virus."
Boxes containing the vaccine are prepared for shipping at the Pfizer Global Supply Kalamazoo manufacturing plant in Portage, Mich., on Sunday.
"Everything's on time, no disruptions, and we're very, very excited," said Wes Wheeler, president of UPS Healthcare, which along with its rival FedEx, is carrying out the mass deliveries.
Still, salvation is a long way off.
Most Americans won't receive the shots until well into next year. And it will take some time to make even a dent in a pandemic that is killing thousands of people across the U.S. every day — more than ever before.
Medical workers will struggle not only to distribute the vaccine to rural areas, but also to convince skeptical members of the public that the shots are safe.
Secretary of Health and Human Services Alex Azar tried to reassure Americans on Monday, telling the "TODAY" show that the vaccine had "gone through every aspect of the FDA process with integrity and transparent data."
"If you are recommended to get it and it's available for you, please do get it, protect yourself and protect those around you," he said.
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Asked exactly how may people would be vaccinated and how quickly, Azar said several times that it was "up to our nation's governors" to decide the specifics.
Over the weekend, Gen. Gustave Perna, the chief operating officer of Operation Warp Speed, likened the distribution operation to the 1944 Normandy landings, the Allied invasion that began the liberation of Nazi-occupied Europe.
"D-Day was a pivotal turning point in World War II. It was the beginning of the end — and that's where we are today," Perna told a briefing Saturday. "But make no mistake, it was not the end. Months and months of hard-fought battles occurred and it took diligence, courage and strength to eventually achieve victory."
Meanwhile, Congressional leaders have set a Friday deadline to pass legislation to keep the government funded, and they say a Covid-19 aid package should be attached to it. However, Democrats and Republicans remain at odds about exactly what should be included in the deal.
The vaccine rollout in the U.S. prioritizes high-risk populations, such as hospital workers and nursing home staff and residents. It's unclear who will be prioritized in the second phase. On Monday, 145 sites will receive the vaccine, 425 Tuesday and 66 Wednesday, making up the rest of the initial shipment, Perna said.
That mirrors what's already happening in the United Kingdom, which last week became the first country to administer a clinically approved vaccine to patients.
A FedEx Express plane carrying a first batch of vaccine arrives at Los Angeles International Airport on Sunday.
That appeared to frustrate Trump, calling the FDA "a big, old, slow turtle" in a tweet Friday, and urged its commissioner, Dr. Stephen M. Hahn, to "get the dam vaccines out NOW" and "stop playing games and start saving lives!!!"
The FDA has repeatedly denied this. "We do not feel that this could have been out a week earlier," Hahn told ABC's "This Week" on Sunday. "We followed our process."
A member of Pfizer's board has also said the Trump administration passed up the opportunity to buy more of the vaccine when it had the chance.
The U.S. has ordered at least 100 million doses of the BioNTech-Pfizer vaccine, with the option to buy another 500 million. Of all the vaccines currently in development, it has put in advance orders for 800 million doses — enough to inoculate its population several times over.
That trend among wealthy countries has concerned global campaigners, who say poorer countries are set for a longer wait because richer countries are looking after themselves first.